GREGoRi Innovation Projects (U01 Clinical Trial Optional)

The Genomics Research to Elucidate the Genetics of Rare Diseases:innovation (GREGoRi) initiative seeks to accelerate a paradigm shift in rare disease diagnosis by reimagining the tools, molecular technologies and analytical approaches used to identify the causal gene(s) and/or variant(s) underlying rare genetic disorders. This Notice of Funding Opportunity is intended to stimulate the development and testing of highly innovative experimental or computational approaches for rare disease diagnosis, that have the potential to make transformative improvements to the current state of the art.

Eligibility

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Public and State controlled institutions of higher education
Private institutions of higher education
Others (see text field entitled "Additional Information on Eligibility" for clarification)
State governments
For profit organizations other than small businesses
Public housing authorities/Indian housing authorities
Native American tribal organizations (other than Federally recognized tribal governments)
County governments
Independent school districts
Special district governments
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
City or township governments
Small businesses
Native American tribal governments (Federally recognized)

Application requirements

1Apply through Grants.gov (SAM.gov registration required).

How to apply

Apply online at https://www.grants.gov/search-results-detail/359644 via Grants.gov. Agency contact: National Institutes of Health — [email protected].

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Holly Clark Management and Program Analyst

Institute of Education Sciences (IES): National Center on Education Research (NCER): From Seedlings to Scale, Assistance Listing Number (ALN) 84.305J

Through the From Seedlings to Scale (S2S) Grants program, IES will invest in innovative ideas within an identified focus area through three phases of increasing funding and duration to support ideas as they grow from seedlings to scalable solutions. Projects will incorporate high-quality research, robust solution development, and attention to sustainability and scaling throughout all phases. For the FY 2027 S2S program, IES invites applications for Phase One projects under the Coordinating Systems to Translate Evidence into Policy and Practice (C-STEP) focus area. C-STEP seeks to develop and rigorously test innovative AI- and technology-enabled solutions that help education systems intentionally integrate evidence-based products, processes, and policies to improve outcomes for prekindergarten through grade 12 students. Proposed solutions should reflect a deep understanding of the systems in which they operate and enable education leaders to align resources, anticipate impacts, and overcome implementation barriers, thereby strengthening the connection between research, policy, and practice. Assistance Listing Number (ALN): 84.305J

Holly Clark Management and Program Analyst

Institute of Education Sciences (IES): National Center for Special Education Research (NCSER): Transformative Research in Special Education, Assistance Listing Number (ALN) 84.324T

Through the Transformative Research in Special Education Grants program, IES seeks to support research and development of transformative solutions to seemingly intractable problems and challenges in special education. Transformative projects enact bold and innovative thinking, involve interdisciplinary collaboration, are inherently risky, and use high-quality research approaches to create high-reward, scalable solutions with the potential to lead to dramatic improvements for students with or at risk for disabilities. In FY 2027, the Transformative Research in Special Education Grants program will focus on Phase 1 grants to research and develop transformative solutions to dramatically improve preservice teacher education systems so they can better attract, train, and retain preK-12 general and special education teachers who are prepared to provide high-quality instruction and substantially improve outcomes for students with or at risk for disabilities. Assistance Listing Number (ALN): 84.324T

$3,750,000Dec 11, 2026

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Nonprofit

University / research

National Endowment for the Humanities

Public Humanities Projects

The National Endowment for the Humanities (NEH) Division of Lifelong Learning is accepting applications for the Public Humanities Projects program. The purpose of this program is to support projects that bring the ideas and insights of the humanities to life in three areas: (1) exhibitions, (2) historic site interpretations, and (3) public lectures and discussions. For 2027, NEH welcomes applications that promote deeper public understanding of the following topics: Western civilization and America’s place in it; great works of literature, history, philosophy, and theology and their relevance to contemporary questions; the 250th anniversary of the American Revolution; civic education; civil discourse; cultural literacy, and the practice of close reading. Public Lectures and Discussion Forums must address one of these interest areas.

$1–$2,000,000Dec 16, 2026

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Geological Survey

Cooperative Agreement for Affiliated Partner with the Colorado Plateau Cooperative Ecosystem Studies Unit (CESU)

U.S. Geological Survey's (USGS), Northern Rocky Mountain Science Center (NOROCK), is offering a funding opportunity to improve assessments of floodplain connectivity and riverscape health. Current approaches to identify floodplain connectivity across the western United States rely on field data, limiting inference and spatial extent of data. However, existing lidar datasets through the USGS provide unique opportunities to develop approaches using lidar elevation data to provide robust estimates of floodplain connectivity. The ultimate use of these data would be to identify factors limiting healthy riverscapes across the Great Basin. The CESU partner in collaboration with NOROCK's research fisheries biologist will advance the ability to evaluate riverscape health by addressing one or more of the following considerations to improve assessments of riverscape health: Develop a workflow for using lidar to estimate floodplain connectivity within riverscapes in the Great Basin. Demonstrate the benefits this approach in comparison to existing methods. Quantify continuous estimates of floodplain connectivity across portions of the Great Basin. Results will be useful to the broader community working to assess and restore the health and ecosystem services of riverscapes in the Western US in relation to drought, land management activities, and fish and wildlife populations. Biologists and geomorphologists from NOROCK and the CESU Partner will collaborate with federal and state agencies and NGO partners to ensure their approach and data are accessible, scalable, and transferable to encourage the uptake by the broader scientific community involved with riverscape health assessments and restoration actions. This project focuses on using remote sensing products to efficiently direct resources to restoration of rivers and riparian areas. Using lidar data to map the health of riverscapes supports: SO 3435 - Implementation of the Expanding Public Lands Outdoor Recreation Experiences Act (June 25, 2025) SO 3442 - Land and Water Conservation Fund Implementation by the U.S. Department of the Interior (September 4, 2025) Improving methods beyond field data by leveraging available lidar data will provide continuous, robust measures of riverscape health, thus supporting and restoring Gold Standard Science approaches: EO 14303 – Restoring Gold Standard Science (May 23, 2025) SO 3441 Implementing the Requirements of Executive Order 14303, Restoring Gold Standard Science, May 23, 2025 (August 29, 2025) Restoring our riverscapes will inform Land and Water Conservation Fund Implementation by the U.S. Department of the Interior: and the lead to improved riverscape health that align with the Implementation of the Expanding Public Lands Outdoor Recreation Experiences Act. Further, the benefits of this project will provide cascading benefits to fish and wildlife, thus recovering populations and species. This falls in line with the goals outlined in: EO 14313 – Establishing the President's Make America Beautiful Again Commission (July 3, 2025) SO 3435 - Implementation of the Expanding Public Lands Outdoor Recreation Experiences Act (June 25, 2025) SO 3442 - Land and Water Conservation Fund Implementation by the U.S. Department of the Interior (September 4, 2025)

$1–$90,00024d left