Real-Time Pathogen-Host Interactome Prediction

Source: sbir.gov Agency: DOD Branch: DARPA Program: SBIR Phase I Topic: DPA26BZ03-DV014 Research Area: When novel or emerging pathogens (bacteria, viruses, parasites) are encountered, characterization of their interactions with human hosts currently requires weeks to months of experimental work, often yielding incomplete understanding. This capability gap limits rapid therapeutic response and countermeasure development. Recent advances in protein language models and large-scale protein-protein interaction (PPI) prediction make computational threat characterization feasible. This topic seeks to de Status: open Requirements: When novel or emerging pathogens (bacteria, viruses, parasites) are encountered, characterization of their interactions with human hosts currently requires weeks to months of experimental work, often yielding incomplete understanding. This capability gap limits rapid therapeutic response and counter